DMD and neuromuscular disease caused by qualitative or quantitative defects of dystrophin: The range of modified mdx-type mouse models of dystrophinopathy with usually more severe phenotypes includes double mutants that also affect, besides the dystrophin levels, the expression of proteins such as the dystrophin-associated component dystrobrevin, the autosomal dystrophin homologue utrophin, myogenic differentiation protein MOD1, and α7-integrin [213,214,215,216].