The most severe form of dystrophinopathy, Duchenne muscular dystrophy, is a primary-muscle-wasting disorder of early childhood [179] with a prevalence of approximately 1 in 5000 live male births [180], which is triggered by a variety of genetic abnormalities in the X-chromosomal DMD gene [181]. The gene discussed is DMD; the disease is neuromuscular disease caused by qualitative or quantitative defects of dystrophin.