IL-33 has already been found to drive multiple scenarios of dysbiosis-associated chronic inflammation, including gastrointestinal [73,74], dental [75,76,77], allergologic [78,79,80], pulmonary [81] and oncologic [82] conditions, and a previous study by Murdaca et al. reviewed the role of the IL-33/IL-31 axis in the development of autoimmune and allergic disorders, including AD [29]. Here, IL31 is linked to Alzheimer disease.