LEP and endometrial cancer: In addition, leptin exposure (100 ng/mL) was demonstrated to induce endometrial cancer cell proliferation and migration mostly in two distinct types of EC: Type 1 (or endometrioid adenocarcinomas), characterized by excess estrogen in the body (around 3–3.5 fold change), and Type 2, which are not linked to excess estrogen (2–2.5 fold change) [200].