ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Hence, recently, researchers have demonstrated that adiponectin plays a pivotal role in the development and possible progression of several types of obesity-associated cancers, such as breast [43,128,129,130,131,132,133,134,135,136,137,138], endometrial and ovarian [139,140], and colorectal [141,142].