Even though T142 was not found within the group of residues having the greatest RMSF differences in the CPR–CYP1A2 interface (Figure 4D), this residue has been identified in humans with perturbed steroidogenesis induced by POR deficiency [6]. Here, CYP1A2 is linked to congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency.