In addition, the plasma level of leptin was associated with many traits of patients with CP, including higher-grade HI (25.85 vs. 16.95, and p = 0.037), preoperative obesity (29.55 vs. 21.13, and p = 0.035), and female gender (32.77 vs. 16.77, and p < 0.001). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.