TGF-β1 can regulate the transcription of protein target genes of the pro-fibrotic response and promote the activation of cardiac fibroblast and protein synthesis of the cardiac extracellular matrix by activating the TGF-β1/SMAD2/3 signaling pathway, which affects the process of cardiac fibrosis and cardiac remodeling in the late stages of MI [5,13]. The gene discussed is SMAD2; the disease is myocardial infarction.