CD4 and autoimmune disease: Using experimental autoimmune encephalomyelitis (EAE) as a model of autoimmune disease, Zhou et al. demonstrated that mice with Alkbh5 knockout specific to T-cells (CD4-Cre, Alkbh5fl/fl) exhibit ~2-fold reduction in lymphocyte infiltration and less spinal cord demyelination compared to wild-type mice and, overall, were resistant to the induction of EAE using immunization with myelin oligodendrocyte glycoprotein peptide (MOG35–55) [48].