Using RIOK3—a transcript that gains m6A peaks in its 3′UTR—the authors showed that during infection with DENV, ZIKV, and HCV, this mRNA is modified in response to the activation of IRF3 and IFN-β and is consequently recognized and bound by YTHDF1, which promotes translation and leads to increased RIOK3 protein levels, even in the context of the global inhibition of cellular translation. Here, IFNB1 is linked to infection.