ACSL1 and obesity due to melanocortin 4 receptor deficiency: For example, the ectopic expression of ACSL1 promotes the accumulation of TAG by 12-fold in cardiomyocytes [8]; eliminating ACSL1 decreases, and overexpressing ACSL1 increases, the TAG synthesis in hepatocytes [9,10]; ACSL1 also facilitates FA uptake and TAG synthesis in mouse 3T3-L1 adipocytes [11], etc. The dysregulation of ACSL1 is involved in obesity [12] and various diseases related to obesity including fatty liver disease [13,14] and diabetes [15,16].