TRPM7 and myalgic encephalomeyelitis/chronic fatigue syndrome: Treatment of NK cells with NS8593 resulted in this difference, suggesting dysregulation involving both the TRPM7 ion channel and kinase components in ME/CFS rather than the ion channel moiety in isolation as the TRPM7 kinase domain regulates TRPM7 ion channel opening, actin dynamics, and translocation of the TRPM7 protein [43].