TRPM7 and myalgic encephalomeyelitis/chronic fatigue syndrome: Notably, pathophysiological changes to the microdomains where NTB or NS8593 act on TRPM7 may cause a reduced binding affinity for these drugs, or conformational instability of the TRPM7 ion channel may limit the duration of action of NTB and NS8593 in the NK cells of ME/CFS patients compared to HCs.