With newer advances in its molecular landscape, medulloblastoma is now classified into four distinct molecular subtypes; WNT-activated, SHH-activated and TP53-WT, SHH-activated and TP53-mutant, and non-WNT/non-SHH which primarily comprise group 3 and group 4 types of this neoplasm [74]. The gene discussed is TP53; the disease is medulloblastoma.