Hence, the present study was carried out to examine: (a) NGF, SCF, SCGF, HGF and M-CSF, in relation to VEGF, PDGF and FGF, and the neurotoxicity immune profile in MDD; and (b) whether NGF or the other growth factors mediate the effects of ACEs and ROI on the depression phenome. This evidence concerns the gene HGF and major depressive disorder.