In addition, one factor could be extracted from ROI and the GF (VEGF, PDGF, and FGF) and the neurotoxicity profile, forming a novel pathway–phenotype that predicts the phenome of depression [11] Such findings demonstrate that ROI and GF/neurotoxicity pathways are intricately intertwined and comprise a crucial aspect of the disease. Here, VEGFA is linked to depressive disorder.