CASP3 and osteochondritis dissecans: This study examined: (1) behaviors linked to OD; (2) the nitrosative and oxidative status; (3) antioxidant power; (4) mitochondrial function; (5) neuroinflammation; and (6) caspase-3 in the striatum of rats, since it has been previously reported that altered striatal nitrosative and oxidative stress, neuroinflammation, mitochondrial dysfunction, and severe neurodegeneration were tightly correlated with HP-induced OD in animal models, mimicking TD observed in clinical settings [4,5,6,7,8,9,10,11,12,28].