CST3 and diabetes mellitus: As shown in Table 5, in the multivariate analysis, diabetes and cystatin C were significantly associated with the interhemispheric difference in the number of the lacuna (OR = 2.03, p = 0.038; OR = 5.73, p = 0.024) and CSVD score (OR = 2.22, p = 0.033; OR = 9.67, p = 0.008).