AQP4 and early-onset autosomal dominant Alzheimer disease: Consequently, both the perturbance of the astrocyte’s vascular end foot that presents the Aqp-4 as well as a decreased glymphatic flow (which can be caused due to the CSD that produces the vasodilation, underlying the physiopathology of the migraine aura) lead to an increased risk of Alzheimer’s disease development [37].