This current study provides several potential advantages by suggesting (1) how pesticides trigger downstream molecular mechanisms and activate pathogenic molecular pathways in PD; (2) the crucial role of these top genes in PD pathology associating pesticide exposure; and (3) the altered expression of these top-ranked genes (CTNNB1, NDUFS6, and CAV1) in PBMC results may pave the way for developing biomarkers that enable the screening of pesticide-associated PD. The gene discussed is CAV1; the disease is Parkinson disease.