By applying Tukey’s multiple comparisons test, it was found that skin erythema of BNLC-E-treated side at baseline visit vs. 1 M, 2 M, and 3 M were found to be insignificant, and skin erythema of O-NLC-E-treated side showed a significant decrease compared to baseline vs. 2 M and 3 M. The decline in erythema level by O-NLC-E provided the evidence that it is attributed to gallic acid and hesperidin via downregulation of inflammatory-cascades, MMP1, and oxidative stress. This evidence concerns the gene MMP1 and neoplasm.