Following general physical and biochemical improvement, therapy with rhGH started 4 years ago, and current results are presented.<h4>Conclusions</h4>The patient with Löwe syndrome who was presented with a 6-year follow-up demonstrates the complexity of rare disease cases and the value of multidisciplinary care together with growth hormone treatment for better results in these patients. Here, GH1 is linked to oculocerebrorenal syndrome.