If anything, the diagnosis made in the index case presented, which led through precision medicine to the discovery of this novel deadly variant in the TP53 gene, and the subsequent timely and hopefully lifesaving interventions in her mother as well as the index case her-self with the early discovery of a new primary osteosarcoma several years later—before any clinical symptoms or signs would appear—could literally have been made to the maternal cousin with the adrenal tumor at the age of 5 months, 15 years ago, meaning the exploitation of a detailed family medical history. This evidence concerns the gene TP53 and osteosarcoma.