Dissimilarities may stem from different prevalences of cardiometabolic risk factors since the studies in the general population of young subjects unequivocally report significant relationships between AIP and proxy measures of obesity, variables of lipid profile, and insulin sensitivity [10,11,12,14], but also, B.P. and uricemia [12,14]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.