A similar trend was observed in the post-mortem brains, with epigenetic age acceleration being observed in PSP patients compared to controls with both DNAmClockMulti and DNAmClockCortical (Figure 3c,f) and a trend towards epigenetic age acceleration in the GRN mutation carriers (FTLD-TDPA) (Figure 3b,e). This evidence concerns the gene GRN and supranuclear palsy, progressive, 1.