Recent studies have also reported several epigenetic modifications in various FTLD subtypes including significant differential methylation in the 17q21.31 locus (which includes MAPT) in the peripheral blood of individuals with PSP, and to a lesser extent in FTD [6]; hypermethylation in DLX1 was also reported in the prefrontal cortex of individuals with PSP [7]. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.