The best-studied lncRNAs with oncogenic potential so far are lncRNA HOX transcript antisense RNA (HOTAIR), the elevated level of which was observed in OSCC [209] and is suspected of promoting metastasis in HNSCC [210], lncRNA metastasis–associated lung adenocarcinoma transcript 1 (MALAT1) with elevated levels in HNSCC [211], and lncRNA urothelial carcinoma antigen 1 (UCA1), which was elevated in tongue squamous cell carcinoma (TSCC) [211]. Here, MALAT1 is linked to head and neck squamous cell carcinoma.