PIK3CA and neoplasm: Farag et al. proves that elevated levels of miR-134 increase the growth and migration of tumor cells by reducing the E-cadherin expression and, further, interacting with Programmed Cell Death 7 in OSCC [177], while Zhou et al. claims that miR-134 inhibits tumor stem cell migration and invasion in OSCC via downregulation of the PI3K-Akt signaling pathway by inhibiting LAMC2 expression [178].