Also, BM-MSCs-Exos containing miR-192-5p suppressed CIA progression in rats via ras-related C3 botulinum toxin substrate 2 [120], and BM-MSC-Exos containing miR-320a repressed RA-FLS proliferation by downregulating CXC chemokine 9 [121], while MSC-Exos containing miRNA-150-5p reduced angiogenesis and FLS proliferation in RA patients and CIA model mice by downregulating MMP14 and vascular endothelial growth factor [122]. This evidence concerns the gene RAC2 and rheumatoid arthritis.