Su et al. [123] recently demonstrated that MSC-Exos also participated in the intercellular transfer of the long noncoding RNA heart- and neural crest derivatives-expressed protein 2 antisense 1, and suppressed the activation of RA-FLSs via miR-143-3p/tumor necrosis factor and alpha-induced protein 3/NF-κB pathways in RA patient synovial tissue and cultured cells, suggesting the potential involvement of these MSC-Exos-evoked signaling cascades in RA pathogenesis and as possible treatment targets. Here, TNFAIP3 is linked to rheumatoid arthritis.