APE1 overexpression occurs also in oesophageal carcinomas, like oesophageal adenocarcinoma (EAC) [102,103,104] and oesophageal squamous cell carcinoma (ESCC) [105,106], probably as a mechanism adopted by cancer cells to survive the genotoxic effects of bile reflux [105,106]. This evidence concerns the gene APEX1 and cancer.