HPSE and glioblastoma: Here, our findings point out an increase of LC3-II amount both in RPE-1 cells and, more evidently, in U87 human glioblastoma cells following HPSE inhibitor RDS 3337 treatment, suggestive of an autophagosomes accumulation and a consistent arrest in the autophagic flux, as confirmed by cell treatment with BafA1.