In another study, also conducted in murine DSS-induced colitis, a recombinant strain of Lactobacillus casei using the pLUAT-ss plasmid was used to make it α-MSH-producing, with positive results on colitis control (in terms of correcting weight loss, myeloperoxidase and histological activity as well as the survival rate of mice) [65]. Here, MPO is linked to colitis.