This hypothesis is consistent with the effects of GBA activity deficiencies in Gaucher’s disease, which result in the accumulation of many different lipid species including sphingolipids [16,21,59], with previous studies showing that EMT in various cancer cell lines is accompanied by alterations in ceramide metabolism [60], and with the results of our untargeted analysis revealing broad lipid metabolism alterations in HeLa GBAKO cells. Here, GBA1 is linked to Gaucher disease.