CDH2 and liver cancer: However, it was also shown that inhibition of GlcCer synthase in the GBAKO hepatocellular carcinoma-derived cells with 1-phenyl-2-decanoylamino-3-morpholino-1-propanol or miglustat reversed the effect on migration and invasion, and decreased N-cadherin and SLUG expression [22], thus suggesting the possibility that, in liver cancer-derived cells, GlcCer synthesis may be one of the main drivers of the phenotypic effects resulting from GBA deletion.