Some of the identified DEGs have been associated with ALS, including three genes up-regulated (ALAD, FBXO32, and USP6NL) or down-regulated (ANXA2, DOC2B, DPP6, and PARK2) in sALS fibroblasts (Supplementary Table S1). Here, FBXO32 is linked to amyotrophic lateral sclerosis.