In particular, interactome analysis identified a cluster of hub genes involved in the regulation of gene expression (ATM, EPHA5, EPAS1, ITGA2, LMO7, NCOA3, PHC2, PARK2, ZNF577, ZNF354A, ZNF69, ZNF493, ZMYND11, ZNF587B, ZNF160, ZNF585B, ZNF641), supporting dysfunctions in the RNA metabolism process and transcriptional machinery as key processes in the pathogenesis of ALS [78,79,80,81,82] (Figure 3B). This evidence concerns the gene PHC2 and amyotrophic lateral sclerosis.