Secondly, NK cells can catalyze differentiation of tumor cells through IFNγ secretion and stimulation [126], which causes remodeling of the surface receptor pattern of tumor cells, including an upregulation in MHC-I and CD54 and a downregulation in CD44 expression, followed by the disturbance of tumor growth and metastasis [127] and being well-recognized and eliminated by T cells. The gene discussed is CD44; the disease is neoplasm.