MPPE1 and neoplasm: Conventional type 1 DCs (cDC1) are important players in regulating cross-priming activation of T cells located in tumor-draining lymph nodes through secreted chemokines and cytokines that are involved in the modulation of T cell viability, capability and infiltration into the tumor microenvironment, which presents the importance of their clinical application for cancer immunity through highlighting their effect on tumor rejection abolishment, responsiveness to CAR-T therapy and ICI in mice with cDC1 deficiency [134,135].