Through further in vivo experiments using fecal microbial transplantation (FMT), mice that were transplanted with FMT from long-term survival patients showed augmentation in tumor infiltration and activation of CD8+ T cells, upregulations of serum IFN-γ and IL-2 and decreased tumor burden, while mice that were transplanted with FMT from short-term survival patients showed enhancement in regulatory T cells and myeloid-derived suppressor cells in tumor infiltration and promoted tumor growth [236]. This evidence concerns the gene CD8A and neoplasm.