Tumoral pAgs bind the intracellular domain of BTN3A1, which is associated and comprises complexes with BTN2A1, and BTN2A1 can be recognized directly by TCR Vγ9 chain [164], while IPP is overproduced by the dysregulated mevalonate pathway in cancer cells, which activates Vγ9Vδ2 T cells [165,166]. This evidence concerns the gene BTN2A1 and neoplasm.