In SARS-CoV-2 infection, TLR-2/6 agonism by INNA-051 has shown promising results in reducing viral RNA levels in a non-sterile infection/inflammation model in ferrets [250]; mouse models have shown that activation of TLRs 2 and 7 induces pro-coagulatory transcription factor expression in (non-sterile) sepsis-induced coagulopathy, making it a possible therapeutic goal in the future [251]. The gene discussed is TLR2; the disease is Sepsis.