NES and drug-induced dyskinesia: In our previous study, dyskinetic rats under L-DOPA monotreatment were found to express high levels of microvascular nestin immunoreactivity (an angiogenesis marker) as well as albumin leakage in the striatum, whereas rats developing dyskinesia upon L-DOPA–ropinirole cotreatment exhibited low levels of nestin and albumin immunoreactivity, not differing significantly from saline-treated controls in this regard [8].