TWIST1 and melanoma: First, we showed that JI130 and MEL56 inhibit cell migration in two invasive melanoma cell lines (MM029 and MM165) (Figure 6A) and downregulate the mRNA expression of the main EMT/invasion markers such as AXL, EGFR, MET, ZEB1, WNT5A, TGFβ, SNAI1, TWIST and MMPs (Figure 6B).