We found that MEL56 and JI130 inhibit cell proliferation with IC50s ranging from 0.08 to 0.25 μM for JI130 and from 4.7 to 15.5 μM for MEL56 in a large panel of representative melanoma lines comprising three with WTBRAF/WTNRAS (HBL, LND1, and MM162), four with BRAF mutations (MM074, MM164, MM029, and MM032) and two with NRAS mutations (MM161 and MM165). This evidence concerns the gene BRAF and melanoma.