Interestingly, we also showed that the combination of PHB ligands with MAPK inhibitors (TKi, BRAFi, and MEKi) display a synergistic effect in terms of growth inhibition and apoptosis induction in melanoma cells with different molecular subtypes including WTBRAF/WTNRAS, BRAF mutant (including innate resistance line), and NRAS mutant melanoma. This evidence concerns the gene NRAS and melanoma.