NR3C1 and hippocampal atrophy: In addition, according to “The glucocorticoid-hippocampal atrophy model”, HPA axis long-term stress-related overstimulation would be responsible for neurotoxicity and thus neurodegeneration of certain brain structures, primarily the hippocampus due to its abundance in glucocorticoid receptors, which, by entailing higher concentration of ROS, lead to oxidative damage at such level [90,91].