In human non-small-cell lung cancer lines, researchers verified that regulating proteins, e.g., lysine-specific histone demethylase 1, regulate tumor metastasis via demethylating the SEPT6 promoter, and the result is overexpressed Septin6, which activates the TGF-β1 pathway [23]. The gene discussed is SEPTIN6; the disease is non-small cell lung carcinoma.