AKT1 and cancer: According to a study by Peng J et al. (2014), which explored the molecular mechanisms underlying GOLPH3’s effects in gastric cancer, uncovering positive regulation of PI3K/Akt/mTOR signaling pathway by GOLPH3, this pathway has long been known for affecting cell survival, proliferation and migration processes as well as epithelial–mesenchymal transition (EMT) markers such as E-cadherin and N-cadherin expression associated with increased cancer cell invasiveness [40].