Deregulation of the CXCR2/ligands signaling has been previously described for further neuropathological diseases (traumatic brain injury, multiple sclerosis, ischemia, Alzheimer’s disease, neuropathic pain) [14,27], but the biological significance of this alteration in ALS remains not fully explained. This evidence concerns the gene CXCR2 and amyotrophic lateral sclerosis.