In the present work, we investigated the expression and localization of both CXCR2 and CXCL8 in spinal cord specimens from control and ALS patients, and inspected the biological and functional role of the CXCR2/ligands axis in murine NSC-34 motor neuron-like cells expressing human wild-type (WT) or mutant G93A-SOD1. The gene discussed is CXCL8; the disease is amyotrophic lateral sclerosis.