We further observed an increased immunoreactivity of the CXCR2 receptor in neuronal cell bodies and axons from ALS motor cortex [9], and functionally showed that receptor inhibition prevent inducible pluripotent stem cells (iPSC)-derived MNs degeneration in vitro and improve SOD1-G93A mice muscular functions in vivo, delaying the onset of neuromuscular decline by four weeks [9]. Here, SOD1 is linked to amyotrophic lateral sclerosis.