Foxc2 and Osterix are the early drivers for endothelial and osteogenic differentiation, respectively, and we have shown that Foxc2 was upregulated by glucocorticoids whereas Osterix was downregulated (Figure 2c and Figure 6b,d), suggesting important roles of Foxc2 and Osterix in the shift of osteoblasts in glucocorticoid-induced osteoporosis. Here, SP7 is linked to osteoporosis.