Altered BDNF expression is observed in AD, and although data is lacking for the effects of RSG on BDNF in humans, in pre-clinical models of T2DM and AD, RSG upregulates BDNF and improves memory and cognition [12,25,26,27,28,29,30,31,32,33,34,35,36]. Here, BDNF is linked to type 2 diabetes mellitus.