In the study by Oberhardt et al., TCM and early differentiated (TED; CD45RA+ CCR7+ CD27+ CD11a+ CXCR3+) CD8+ T cell subsets specific for SARS-CoV-2 spike peptide-loaded HLA class I tetramers (HLA-A*01-restricted Spike (S)865, (HLA-A*01/S865) and HLA-A*02/S269) and transitional memory (TTM; CD45RA+CCR7− CD27+) CD8+ T cells specific for HLA-A*03/S378 were more dominant in convalescent individuals after 80 days of natural infection, while TEM were more prevalent in vaccinees at the same timepoint [19]. This evidence concerns the gene CD27 and infection.