SLC8A3 and Alzheimer disease: In light of this evidence and the fact that alteration of Ca2+ handling is a central driver of AD progression, in the present study, we aimed to elucidate the role of NCX1 and NCX3 in an in vitro model of retinoic-acid (RA) differentiated SH-SY5Y cells, where the exposure to GA induces a glucose metabolism impairment [14,36].