Interestingly, our previous studies revealed that, in energy metabolism-compromised states like cardiac and neuronal hypoxia/reoxygenation injury and neurodegenerative models such as AD and Parkinson’s disease (PD), NCX1 plays an essential role for the metabolic use of glutamate to sustain mitochondrial ATP production and guarantee improved survival [36,37,38]. Here, SLC8A1 is linked to Alzheimer disease.