Specifically, anti-nuclear antibodies (ANA), rheumatoid factor (RF), HLA-B27 antigen, and anti-cyclic citrullinated peptide (CCP) antibodies are used for patient classification, while erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are utilized for the definition of the Juvenile Arthritis Disease Activity Score (JADAS) [2,16,17,30], a composite scoring for the assessment of disease clinical activity [18,36]. This evidence concerns the gene CRP and Arthritis.