One possible explanation for the correlation of high HSPD1 expression with increased sensitivity to mitosis-targeting drugs can be attributed to the fact that epithelial ovarian cancer is highly dependent on OXPHOS to maintain tumor growth and progression [35], and it was reported that high-OXPHOS ovarian cancer cell lines exhibit an increased response to conventional chemotherapies [35]. The gene discussed is HSPD1; the disease is ovarian carcinoma.