Regarding the influence of PTHrP on senescence features led by inflammatory diseases, such as osteoarthritis (OA), in osteoblasts, the study by Platas et al. [35] showed that the C-terminal peptides PTHrP (107–111) and (107–139), but not the N-terminal domain, were able to reduce remarkably the expression of senescence markers induced in vitro by treatment of OA osteoblasts with IL-1β. Here, PTHLH is linked to osteoarthritis.