LAG3 and neoplasm: ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) or HER3 or human epidermal growth factor receptor 3 (EGF3) methylation in CC also supports immunosuppressive TIME by regulating different chemokines (CXCL9, CXCL5, CXCL13, CXCL11, CCL19, CCL18, CCL21, and CCL22) and tumor-immune lymphocyte (TIL) infiltration and expression of different immune checkpoints, including T-cell immunoreceptor with Ig and ITIM Domains (TIGIT), CTLA4, and lymphocyte activation gene 3 (LAG3) [122].