Another aspect that is also extremely interesting, but for a different reason, is the downregulation of haptoglobin in CHD, which is produced by the liver and whose most important function is to recycle heme iron in the liver by combining itself with free plasma hemoglobin, which in addition to being a positive acute phase protein (increasing in case of inflammation) was found to be markedly decreased in canine late stage cirrhosis [26], aspects that would seem to justify our findings. Here, HP is linked to coronary artery disorder.