Then, analyzing proteins that were less abundant in DHD and CHD, Annexins A2 and A4 are both calcium-dependent phospholipid-binding proteins involved in exocytosis and are upregulated in different neoplasms, including hepatocellular carcinoma and liver fibrosis [35,36,37,38]. Here, PLA2G4A is linked to Doyne honeycomb retinal dystrophy.