The pro-inflammatory cytokines IL-1β, IL-6 and TNF-α can enhance systemic or local inflammatory responses, aggravate histopathology and disrupt intestinal barrier function, leading to the development of enterocolitis, while the anti-inflammatory factor IL-10 has a negative feedback regulatory effect and can reduce the production and release of pro-inflammatory cytokines [35]. This evidence concerns the gene IL6 and enterocolitis.