SDHB is the most commonly mutated of all the SDH-related genes, with >180 mutations that have been associated with extra adrenal, head or neck paraganglioma, adrenal pheochromocytoma, Carney–Stratakis syndrome, renal cell carcinoma, GIST, and infantile leukodystrophy. The gene discussed is SDHB; the disease is adrenal gland pheochromocytoma.