Notably, Arunsundar et al. also demonstrated that HT restored the expression of genes involved in the regulation of survival and memory functions: SIRT1, cAMP response element-binding protein (CREB), and CREB target genes that regulate cognitive functions and ADAM10, a SIRT1-regulated metalloprotease down-regulated in AD [48]. Here, CREB1 is linked to Alzheimer disease.