Another flavonoid, coenzyme Q10, a natural lipophilic compound, has demonstrated in murine glaucoma models its ability to reduce glutamate excitotoxicity and oxidative stress, promoting RGC survival and preventing apoptotic cell death by decreasing Bax expression and increasing the Bcl-2 associated agonist of cell death (Bad) protein expression [266]. The gene discussed is BCL2; the disease is glaucoma.