CYBB and endothelial dysfunction: Hyperglycemia was also described to be a cause of endothelial dysfunction and oxidative stress in the retina [147,148,149] via the involvement of NOX2 due to the activation of the receptor of an advanced glycation end product (RAGE)-, mitogen-activated protein kinase (MAPK)-, polyol-, protein kinase C (PKC)-, renin–angiotensin system (RAS) signaling pathways [150,151,152,153,154,155].