APEX1 and amyotrophic lateral sclerosis: Furthermore, it has an important role in controlling cellular response to oxidative stress and inflammation [95] APE1 expression varies in different tissues, and its expression is generally increased in the nervous system, being particularly high in the brain and spinal cord of patients with amyotrophic lateral sclerosis (ALS) and in the cerebral cortex of Alzheimer’s disease patients, as an adaptive response to oxidative stress [96].