A family of 6-substituted aza-anthraquinones was designed taking into account the pharmacological activities previously described for 9,10-anthraquinones and alkaloids with an aza-anthraquinone core, particularly those related to Alzheimer ́s disease: inhibition of AChE, BChE (butyrylcholinesterase) and Aβ fibril formation and deposition. The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.