ACHE and early-onset autosomal dominant Alzheimer disease: In the course of a project aiming at the identification of natural products as multitarget compounds against Alzheimer’s disease, this compound was found to inhibit beta-site amyloid precursor protein cleaving enzyme (beta-secretase 1, BACE-1), acetylcholinesterase and butyryl cholinesterase, with a balanced multitarget profile [88].