Hence, several studies using an in vivo mice model of AD such as Tg2576 and APP695SWE proved that EGCG induces PKCε-mediated ECE-1 activation and promotes the non-amyloidogenic processing of APP through PKC activation, promoting sAPPα production and a significant reduction in Aβ and amyloid plaque levels in the brain [158] (Figure 5 (19–22)). This evidence concerns the gene APP and Alzheimer disease.