In Alzheimer’s disease, Aβ-induced oxidative stress and microglial activation have both proven to be mediators of MAPK p38 signalling [166,167,168], which promotes apoptosis but also acts as a kinase of tau protein [169], further contributing to Alzheimer’s disease (Figure 6 (9,10)). The gene discussed is MAPK1; the disease is early-onset autosomal dominant Alzheimer disease.