Other AD-related pathological changes, such as mitochondrial dysfunction and mitochondrial dynamics alteration seem to be mediated by ERK pathways, since their blockage has been shown to improve mitochondrial morphology and function and reverse alteration in the expression and distribution of mitochondrial dynamics’ proteins such as DLP1 and Mfn2 [171] (Figure 6 (8)). This evidence concerns the gene MAPK1 and Alzheimer disease.